NFL Week 5 Betting: Five best PrizePicks plays

• Bet Tyreek Hill to find the end zone: The Giants are giving up the fourth-most points per game (30.5) through Week 4.

• Bet Brandon Aiyuk to go over 55.5 receiving yards: He has a tough matchup versus a dominant Cowboys defense, but if San Francisco is going to move the ball through the air, Aiyuk will be leading the way.

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If you have never played PrizePicks, you are in for a treat. You choose two or more players from the board and whether they go over or under their projected fantasy score or single stat. The payout increases with each leg added, similar to a parlay bet.

For each week of the 2023 NFL season, we'll be making a list of our favorite picks. You can take these picks and make a two-, three-, four-, five- or six-leg entry. Let’s get started ahead of Week 5.

Josh Allen OVER 2.5 TDs (Rushing, Receiving and Passing)

Playing in London this week, Josh Allen has been on a tear since starting the season 0-1. In that span, he leads the league in adjusted completion percentage, touchdown passes and passer rating.

Tyreek Hill OVER 0.5 pass + rush + rec TDs

The explosive Dolphins' offense versus the not-so-great Giants' defense just screams mismatch. The Giants are giving up the fourth-most points per game (30.5) through Week 4. After the Dolphins were beaten badly last week, I like their offense to bounce back with Tyreek Hill finding the end zone.

Mark Andrews + Zay Flowers OVER 0.5 TDs (combination of rushing and receiving)

For this combo bet, we just need either Mark Andrews or Zay Flowers to hit paydirt. Andrews leads the Ravens with three receiving touchdowns on the season, and Flowers is waiting to get his first career score out of the way. I like one of these two to help lead the Ravens past the Steelers.

Brandon Aiyuk OVER 55.5 receiving yards

Aiyuk is the 49ers' WR1 and has been the highest-graded wide receiver in all of football this season. He has a tough matchup versus a dominant Cowboys defense, but if San Francisco is going to move the ball through the air, Aiyuk will be leading the way.

Patrick Mahomes OVER 285.5 passing yards

After a game in which Zach Wilson outplayed him, Patrick Mahomes should light up a very suspect Vikings secondary. Mahomes leads the NFL in games with more than 285 passing yards (33).